Generative Modeling with Conditional Autoencoders: Building an Integrated Cell

We present a conditional generative model to learn variation in cell and nuclear morphology and the location of subcellular structures from microscopy images. Our model generalizes to a wide range of subcellular localization and allows for a probabilistic interpretation of cell and nuclear morphology and structure localization from fluorescence images. We demonstrate the effectiveness of our approach by producing photorealistic cell images using our generative model. The conditional nature of the model provides the ability to predict the localization of unobserved structures given cell and nuclear morphology.